MAKING A REAL DIFFERENCE IN CANCER.

57%

Our sensitivity biomarker is found in 19 types of cancer at a prevalence (by type).
We show that NMT2 expression is lost in numerous cancers.

23%

Overview

Pacylex: Targeting myristoylation to selectively kill cancer.

Pacylex Pharmaceuticals, Inc. is developing a precision medicine solution for multiple common cancers. Our approach exploits a previously-unknown therapeutic target in cancer, a cellular process termed myristoylation, which is an essential process allowing many signaling proteins to propagate signals across cell membranes. Our initial indications of interest are blood cancers including leukemia and lymphoma to be followed by numerous solid tumour types. Our drug, PCLX-001, is a first-in-kind therapy.

Our diagnostic technology identifies those patients who will benefit from our drug, sparing many patients needless treatment. We are able to do this through our discovery that a subset of patients across many cancer types have lost one of the two proteins required for myristoylation, N-myristoyl transferase 2 (NMT2). This protein loss presents a therapeutic opportunity for our drug candidate, PCLX-001.

New Driver Biology

NMT2 Loss

NMT2 expression is lost in numerous cancers. The prevalence of the loss reaches 70- 82% in several leukemias and lymphomas. This NMT2 loss appears to promote tumorigenesis but also exposes an Achilles heel that allows new treatment strategies.

Orally bioavailable small molecule

PCLX-001

Our drug is an orally bio-available small molecule that is optimized for NMT inhibition. PCLX-001 has promising attributes of a one pill per day dose strategy and has been shown to be active across many cancer types.

19 Cancer types

Sensitivity Biomarker

We find 19 types of cancer have our sensitivity biomarker,at a prevalence of 5% to 80% of individual cancers. Sensitivity biomarkers are more common in blood and immune system cancers.

Targeting Urgent Needs

Despite major advances in cancer care, many patients don’t survive long after their diagnosis. Fewer than one third of patients diagnosed with lung cancer or acute myeloid leukemia survive for 5 years. Our lead cancer drug eliminates leukemia and lymphoma tumors and inhibits lung and breast cancer tumors in many animal models including with drug resistant patient tumor tissue. We are working now to bring this new medicine to human clinical studies.

Survival Rate

Breast

90%
87%

Hodgkin Lymphoma

74%

Non Hodgkin
Lymphoma

58%

Diffuse Large B-cell Lymphoma

53%

Myleoma

29%

Acute Myeloid Leukemia

19%

Lung & Bronchus

The Team

Michael J. Weickert
CEO

Luc G. Berthiaume
Co-founder and CSO

John Mackey
Co-founder and CMO

Ryan Heit
Co-founder and COO

Michael J. Weickert

Michael has been in biotech and pharmaceuticals for over 26 years, as CEO of illumiSonics, Sonescence, and SEA Medical Systems, CBO of Strategent Life Sciences, Corium, and Therashock, COO of Ohm Oncology, VP of development at SciDose and Auspex, and Senior Program Executive or Manager at Nektar and Ligand. Key roles included raising capital, establishing and maintaining business partnerships, building teams, and developing new products. He raised Seed through Series C capital and established partnerships worth more than $175 Million.

Pipeline of Indications for PCLX-001

Pacylex News

Pacylex

Two Pacylex abstracts accepted for presentation at the American Association for Cancer Research (AACR) conference

Pacylex submitted two abstracts for presentation at the 2019 American Association for Cancer Research (AACR) conference and both have been accepted. The AACR Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cance...

Pacylex

Pacylex presents at 2019 Biotech Showcase

Pacylex presented its exciting anti-cancer story on January 7, 2019, at the 2019 Biotech Showcase™, an investor conference devoted to providing private and public biotechnology and life sciences companies with an opportunity to present to, and meet with, investors and pharmaceutical executives in ...

Pacylex

Grand Opening of Merck Accelerator in Edmonton; Pacylex one of first 4 companies accepted

In partnership with the University of Alberta, Merck launched the Merck Invention Accelerator in a grand opening in Edmonton, Alberta, October 26, 2018. Pacylex was selected as one of the first 4 companies to participate in the accelerator program. This program consists of mentorship, space and fund...

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Our Story

Dr. Luc Berthiaume’s team at the  University of Alberta (U of A) showed that many human cancers lose a protein needed to keep growth and proliferation in check. These cells then become very sensitive to low dose NMT inhibitor treatments while normal tissues are unaffected. This discovery triggered the creation of a U of A spinoff company, Pacylex Pharmaceuticals Inc., to commercialize a diagnostic test to identify patients with NMT inhibitor sensitive cancers.

Independently, the University of Dundee Drug Discovery program developed NMT inhibitors to treat parasitic infections.   Pacylex then in-licensed the rights to Dundee's panel of drug candidates - our lead compound is called PCLX-001. By combining Pacylex’s diagnostic test with the Dundee drug, we have a precision medicine approach to selectively treat patients with cancers sensitive to PCLX-001.

Michael J. Weickert
Luc G. Berthiaume
John Mackey
Ryan Heit

Overview

Pacylex is developing

We have demonstrated:

PCLX-001 eradicates established tumours in three lymphoma or leukemia cell line xenograft studies

PCLX-001 achieves tumour regression, comparable to standard-of-care treatment, in solid tumour xenograft studies

Our new synthetic pathway reduces the 13 step synthesis of PCLX-001 to 3 steps with high yield; this new proprietary medicinal chemistry is of broad applicability

Multiple common cancer types have the biomarker for drug sensitivity based on:

  • RNA level data in cells from 19 types of cancer
  • Protein level data in clinical samples from 11 types of cancer (survey ongoing)

Our sensitivity biomarker test performs well in formalin-fixed paraffin-embedded clinical tumour samples, standard methodology in clinical pathology

PCLX-001 eradicates established drug-refractory aggressive lymphoma in a patient derived xenograft study

TALK TO PACYLEX

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