World’s Longest Baseball Game raises funds for PCLX-001 development.

Pacylex co-founders, Luc Berthiaume, PhD (also Pacylex CSO) and John Mackey (also Pacylex CMO), MD, pose with Erwan Beauchamp, PhD, Pacylex Senior Scientist, as the World’s Longest Baseball Game is about to start.


The "World’s Longest Baseball Game" was played in Edmonton on August 22-25, 2019. More than 50 players spent 84 hours unofficially breaking the word record in a fundraiser for the Cure for Cancer Foundation. Over $500,000 CAD was raised to support the development of Pacylex’s lead drug, PCLX-001, currently on track for patient dosing next year. The event is part of a series of World’s Longest Games that Brent Saik has organized to support Cancer research.

Pacylex is honored and grateful to have our project aimed at the development of our lead candidate drug, PCLX-001, for the treatment of patients with blood cancers, chosen as the beneficiary of the support. Dr. Luc Berthiaume, the founder of Pacylex, identified our drug candidate in a collection of compounds from the University of Dundee and made the crucial discoveries in his lab at the University of Alberta showing that blood cancers cells are especially vulnerable to PCLX-001 while normal healthy cells are spared. Pacylex now has exclusive license to the entire compound family originating from the University of Dundee.

PCLX-001 is anticipated to reach the first cancer patients at the University of Alberta’s Cross Cancer Institute next year. The focus of this first clinical trial will be on patients with lymphoma (Diffuse Large B-cell Lymphoma) and various solid tumor malignancies.

The week prior to the baseball game, the company received pre-IND (Investigational New Drug) meeting feedback from the US FDA. This meeting enables a company to ask questions of the US Food and Drug Administration clarifying or defining the steps necessary to begin a drug into clinical testing in the US. Similar steps are required in Canada. The pre-IND meeting feedback provided a clear path to initiating clinical studies in the US.

Clinical researchers at the MD Anderson Cancer Center in Houston are in discussions with Pacylex on opening a clinical trial in Acute Myelogenous Leukemia as well in 2020.

Below are additional links to stories about the game:


October 10, 2019